Lately, the world’s biggest threats have been microscopic in size. From the global COVID-19 pandemic to wildfires ripping through the U.S. West Coast, it seems as though our lungs can’t catch a break, or more aptly, a breath. But just how small are the particles we’re currently battling? And how does their size compare to other tiny molecules?
Specks Too Small to See
While the coronavirus that causes COVID-19 is relatively small in size, it isn’t the smallest virus particle out there. Both the Zika virus and the T4 Bacteriophage—responsible for E. coli—are just a fraction of the size, although they have not nearly claimed as many lives as COVID-19 to date. Coronavirus particles are smaller than both red or white blood cells, however, a single blood cell is still virtually invisible to the naked eye. For scale, we’ve also added in a single human hair as a benchmark on the upper end of the size range. On the other end of the spectrum, pollen, salt, and sand are significantly larger than viruses or bacteria. Because of their higher relative sizes, our body is usually able to block them out—a particle needs to be smaller than 10 microns before it can be inhaled into your respiratory tract. Because of this, pollen or sand typically get trapped in the nose and throat before they enter our lungs. The smaller particles particles, however, are able to slip through more easily.
Smoky Skies: Air Pollution and Wildfires
While the virus causing COVID-19 is certainly the most topical particle right now, it’s not the only speck that poses a health risk. Air pollution is one of the leading causes of death worldwide—it’s actually deadlier than smoking, malaria, or AIDS. One major source of air pollution is particulate matter, which can contain dust, dirt, soot, and smoke particles. Averaging around 2.5 microns, these particles can often enter human lungs. At just a fraction of the size between 0.4-0.7 microns, wildfire smoke poses even more of a health hazard. Research has also linked wildfire exposures to not just respiratory issues, but also cardiovascular and neurological issues. Here’s an animated map by Flowing Data, showing how things heated up in peak wildfire season between August-September 2020:
What’s the main takeaway from all this? There are many different kinds of specks that are smaller than the eye can see, and it’s worth knowing how they can impact human health. on They can take many forms, from the venom of a snake or spider to the neurotoxins produced by certain types of algae or microbes. In the infographic above, we look at some common biotoxins in the natural world and rank them based on how deadly they are to an average 70 kg (154 lb) human being.
Ranking Biotoxins on a Toxic Scale
A basic concept in toxicology is that “only the dose makes the poison”. Everyday harmless substances like water have the potential to be lethal when consumed in large enough concentrations. Measuring a lethal dosage is very difficult. First, living things are complex: factors like size, diet, biochemistry, and genetics vary across species. This makes it difficult to qualify toxicity in a universal way. Second, individual factors like age or sex can also affect how deadly a substance is. This is why children have different doses for medications than adults. Third, how a poison is taken into the body (orally, intravenously, dermally, etc.) can also impact its deadliness. As a result, there are many ways to measure and rank toxicity, depending on what substance or organism is under investigation. Median lethal dose (LD50) is one common way for measuring toxicity. LD50 is the dose of a substance that kills 50% of a test population of animals. It is commonly reported as mass of substance per unit of body weight (mg/kg or g/kg). In the graphic above, we curate LD50 data of some select biotoxins found in nature and present them on a scale of logarithmic LD50 values. What’s surprising is just how potent some toxins can be.
Bits and Bites about Biotoxins
While one would think that biotoxins are avoided at all costs by humans, the reality is more complicated. Here are some interesting facts about biotoxins present in nature, and our unusual relationships with the organisms that create them:
- Fungi and molds make poisons called mycotoxins Mycotoxins are a global problem. They affect crops from many countries, and can cause significant economic losses for farmers and food producers.
- Phytotoxins can defend plants…and attack cancer Plants use phytotoxins to defend themselves other organisms, like humans. Urushiol, for example, is the main toxic component in the leaves of poison ivy, poison oak, and sumac. But the Pacific yew tree produces taxol that’s valuable in chemotherapy treatments.
- Fire salamander toxin is an ingredient in Slovenian whisky Though not widely available, some whisky makers in Slovenia use samandarine from the fire salamander to create a psychedelic alcohol.
- Ciguatoxins exist in the guts of reef fish Very unique species of bacteria living in the digestive tract of reef fishes make ciguatoxin. They transmit this poison to other organisms when the host fish is eaten.
- Pufferfish are deadly, but also delicious Pufferfish contain tetrodotoxin, a potent neurotoxin in their ovaries, liver, and skin called tetrodotoxin. Despite being a delicacy in many countries around the world, it has a lot of strict regulations because of its ability to kill people. In Japan, for example, only specially licensed chefs can prepare pufferfish for consumption.
- Batrachotoxin is lethal to the touch The skin of some poison dart frogs secretes a deadly substance called batrachotoxin. It is so potent that simply touching the poison can be fatal. Indigenous people of Central and South America used batrachotoxin to poison the tips of hunting weapons for centuries.
- Botox contains the most deadly biotoxin known Commercial botox uses an extremely small amount of biotoxin from a microbe called Clostridium botulinum. It paralyzes the muscles, preventing contraction (i.e. wrinkling). It is the deadliest known biotoxin on Earth. One gram of botulinum toxin can kill up to one million people.
Caveats of Measuring and Reporting Biotoxicity
While we use LD50 data to rank biotoxicity, it isn’t an exact science. There is room for improvement. For starters, no LD50 data exists for humans. That means data from other organisms has to be converted to apply to humans. There is a lot of contention amongst scientific communities about how accurate this is. There has also been an increasing effort to move to new methods of measuring toxicity that are not harmful to animals. Several countries, including the UK, have taken steps to ban the oral LD50, and the Organisation for Economic Co-operation and Development (OECD) abolished the requirement for the oral test in 2001. Now, new ways of evaluating toxicity are under investigation, like cell-based screening methods. Correction: Water was mislabeled on a previous version of the infographic. Full sources here
